Lau, T.-K. and Bischof, W. F. (1991). Automated detection of breast tumors using the asymmetry principle. Computers and Biomedical Research, 24, 273-295.

A method for automated detection of breast tumors in mammograms is presented. The method uses the asymmetry principle: Strong structural asymmetries between corresponding regions in the left and right breast are taken as evidence for the possible presence of a tumor in that region. Asymmetry detection is achieved in two steps. First, mammograms are aligned, compensating for possible differences in size and shape between the two breasts. Second, asymmetry between corresponding positions is determined using a combination of several asymmetry measures, each responding to different types of asymmetries. Results obtained with a set of mammogram indicate that this method can improve the sensitivity and reliability of systems for automated detection of breast tumors.

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