Data-structure splicing techniques, such as structure splitting, field reordering, and pointer inlining reorganize data structures to improve cache and translation look-aside buffer (TLB) utilization. Structure types are typically transformed globally in the program, requiring updates to all references to elements of a transformed type. These techniques often rely on instrumentation, tracing, or sampling to create models that guide their transformations. Furthermore, compilers often cannot prove that their transformations are legal and must rely on manual inspection and manual transformation. Applying data-layout transformations locally – as opposed to globally – to regions of code removes the need for expensive profiling and simplifies legality verification. This work introduces RebaseDL, a static analysis that finds profitable and legal region-based data layout transformation opportunities that improve access locality. These opportunities are found within code regions that exhibit data reuse. Going beyond structure splicing, RebaseDL also identifies transformation opportunities that do not involve structure types, that is, it identifies data packing transformations. The analysis is implemented in LLVM and it detects multiple transformation opportunities within the SPEC CPU benchmark suite, where the transformation obtains speedups of up to 1.34x for transformed regions.